Sublingual vaccination and delivery systems
نویسندگان
چکیده
Most infectious agents use mucosal tissues as entry portals, thus, mucosae are frequently defined a first line of defense against pathogens. Mucosal protection generally operates through antibody-mediated and cytotoxic T-cell responses which can be triggered by vaccines. Sublingual vaccination provides many advantages such systemic (both locally at remote sites), besides being needle-free administration route with high patient compliance limited adverse effects. Buccal mucosa complexity nonetheless represents challenge for vaccine administration, hence, efforts were recently deployed to improve components, mucoadhesion and/or penetration. Several innovative approaches indeed confirmed that robust protective immunity achieved sublingual This review will then specify the most recent delivery systems improvements developed increase vaccines efficiency. We focus our description on immune mechanisms involved requirements optimal immunization protection.
منابع مشابه
Delivery systems for intradermal vaccination.
Intradermal (ID) vaccination can offer improved immunity and simpler logistics of delivery, but its use in medicine is limited by the need for simple, reliable methods of ID delivery. ID injection by the Mantoux technique requires special training and may not reliably target skin, but is nonetheless used currently for BCG and rabies vaccination. Scarification using a bifurcated needle was exten...
متن کاملSublingual Delivery of Vaccines
Sublingual immunization, where the vaccine is placed directly under the tongue and absorbed through the sublingual mucosa, has the advantages of ease of delivery without the complication of oral administration or the safety concerns of intranasal vaccines. Sublingual vaccine delivery has been shown to induce development of humoral and cell mediated immunity in both the systemic and mucosal comp...
متن کاملNovel transdermal drug delivery systems
Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Meth...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2021
ISSN: ['1873-4995', '0168-3659']
DOI: https://doi.org/10.1016/j.jconrel.2021.03.017